| Identification | Back Directory | [Name]
Sibrafiban | [CAS]
172927-65-0 | [Synonyms]
Sibrafiban
WBNUCLPUOSXSNJ-UHFFFAOYSA-N
Acetic acid, 2-[[1-[(2S)-2-[[4-[(Z)-amino(hydroxyimino)methyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-, ethyl ester | [Molecular Formula]
C20H28N4O6 | [MOL File]
172927-65-0.mol | [Molecular Weight]
420.46 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 33.33 mg/mL (79.27 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.16±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Antithrombotic; fibrinogen receptor antagonist; platelet aggregation inhibitor. | [Definition]
ChEBI: Sibrafiban is a N-acylglycine. | [in vivo]
The effects of Ro 44-3888 on the platelet aggregation response to ADP (17 μmol) and on cutaneous bleeding times is determined in 8 rhesus monkeys given Sibrafiban 0.25 mg/kg/day or 0.5 mg/kg/day orally for 8 days. The maximum inhibition of ex vivo platelet aggregation and prolongation of bleeding time by Ro 44-3888 are dose dependent[1]. |
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