| Identification | Back Directory | [Name]
(+/-)-PROPIONYLCARNITINE CHLORIDE | [CAS]
17298-37-2 | [Synonyms]
Hsdb 7589
Propionyl Carnitine
O-propanoyl-L-carnitine
(+/-)-Propionylcarnitinechloride
(+/-)-PROPIONYLCARNITINE CHLORIDE
3-propanoyloxy-4-trimethylammonio-butanoate
3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt
1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-, inner salt | [Molecular Formula]
C10H20ClNO4 | [MDL Number]
MFCD00209823 | [MOL File]
17298-37-2.mol | [Molecular Weight]
253.72 |
| Hazard Information | Back Directory | [Uses]
Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency[1][2]. | [Definition]
ChEBI: O-propanoylcarnitine is an O-acylcarnitine compound having propanoyl as the acyl substituent. It has a role as an analgesic, an antirheumatic drug, a cardiotonic drug, a peripheral nervous system drug and a human metabolite. It is functionally related to a propionic acid. | [in vivo]
Propionylcarnitine (2 mM/kg; p.o. for 4 weeks) affects plasma and urine total carnitine concentrations of mice[3]. | Animal Model: | Adult age-matched male C57BL/6 mice[5] | | Dosage: | 2 mM/kg/day | | Administration: | Oral gavage; 2 mM/kg/day for 4 weeks | | Result: | Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice.
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| [IC 50]
Human Endogenous Metabolite | [References]
[1] Jacobs PL, et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr. 2009;6:9. Published 2009 Apr 2. DOI:10.1186/1550-2783-6-9
[2] Kowal A, et al. Propionylcarnitine and methionine concentrations in newborns with hypospadias. Cent European J Urol. 2013;66(3):377-380. DOI:10.5173/ceju.2013.03.art36
[3] Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9. PMID:7852033
[4] Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. DOI:10.1006/bbrc.1994.1321
[5] Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25. DOI:10.1007/s00394-013-0631-6
[6] Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during hypoxia. Int J Tissue React. 1991;13(1):37-40. PMID:1889961 |
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