| Identification | Back Directory | [Name]
thiocoraline | [CAS]
173046-02-1 | [Synonyms]
thiocoraline
L-Cysteine, N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-cysteinylglycyl-N-methyl-L-cysteinyl-N,S-dimethyl-, bimol. (4→1'),(4'→1)-bis(thiolactone), cyclic (3→3')-disulfide | [Molecular Formula]
C48H56N10O12S6 | [MDL Number]
MFCD00943373 | [MOL File]
173046-02-1.mol | [Molecular Weight]
1157.39 |
| Chemical Properties | Back Directory | [Boiling point ]
1499.6±65.0 °C(Predicted) | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | [form ]
A solid | [pka]
6.88±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC50s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms[1]. | [storage]
Store at -20°C | [References]
[1] Romero F, et al. Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities. J Antibiot (Tokyo). 1997 Sep;50(9):734-7. DOI:10.7164/antibiotics.50.734 |
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