| Identification | Back Directory | [Name]
duclauxin | [CAS]
1732-37-2 | [Synonyms]
(8R,16S)-16-Acetoxy-8a,15aβ-dihydro-4,11-dihydroxy-8aβ-methoxy-6,9-dimethyl-7H-8,15bα-methano-1H,3H,12H-benzo[de]cyclohepta[1,2-g:3,4,5-d'e']bis[2]benzopyran-3,7,12,15(8H)-tetrone | [Molecular Formula]
C29H22O11 | [MOL File]
1732-37-2.mol | [Molecular Weight]
546.48 |
| Chemical Properties | Back Directory | [Melting point ]
230 °C | [Boiling point ]
891.0±65.0 °C(Predicted) | [density ]
1.66±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A solid | [pka]
6.50±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
Duclauxin decreases proliferation of tumor cells in vitro and increases the lifespan of mice innoculated with Ehrlich ascitic tumor cells. Duclauxin (10-30 μg/mL) inhibits mitochondrial respiration of P-388 tumor cells and nucleic acid synthesis in cell culture of Ehrlich cancer, the lymphadenomas NK/LI and L 5178, and sarcoma 37. Duclauxin also inhibits growth of wheat coleoptile. | [References]
[1] Fusková, et al. In vitro effect of duclauxin and derivatives of coumarin on nucleic acid and protein synthesis in Ehrlich’s Ascites Carcinoma cells (EAC). Pharmazie 32(5), 291-293 (1977). |
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