| Identification | Back Directory | [Name]
Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) | [CAS]
173340-25-5 | [Synonyms]
cc-000004
R-3-N-Boc-aMinoMethypyrrolidine
(R)-3-N-Boc-aminomethylpyrrolidine
tert-Butyl (3R)-pyrrolidin-3-ylmethylcarbamate
tert-butyl N-[(3R)-pyrrolidin-3-ylmethyl]carbamate
(R)-3-N-Boc-aminomethyl pyrrolidine, CAS 173340-25-5
1,1-Dimethylethyl N-[(3R)-3-pyrrolidinylmethyl]carbamate
(R)-1-pyrrolidin-3-ylmethylcarbamic acid tert-butyl ester
Carbamic acid, N-[(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester
Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD06796615 | [MOL File]
173340-25-5.mol | [Molecular Weight]
200.278 |
| Chemical Properties | Back Directory | [Boiling point ]
303.9±15.0 °C(Predicted) | [density ]
0.997±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
12.71±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
(R)-tert-butyl pyrrolidin-3-ylmethylcarbamate is a useful reagent in the research discovery of ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate, a catalytic inhibitor of DNA gyrase and a potential antibacterial agent. | [Synthesis]
General procedure: tert-butyl (R)-(1-benzylpyrrolidin-3-ylmethyl)carbamate (1.00 g, 3.44 mmol) was mixed with 20% Pd/C and subjected to hydrogenation under hydrogen pressure of 50 psi.After 48 h, the reaction mixture was filtered to remove the catalyst, and the filtrate was concentrated to give 511 mg of tert-butyl (3R)-pyrrolidin-3-methylcarbamate ( Yield: 74%). Mass spectrometry analysis (APCI+): m/z 201 ([M + H]+). | [References]
[1] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 87; 88; 121
[2] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 115; 116; 149 |
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