| Identification | Back Directory | [Name]
Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) | [CAS]
173340-26-6 | [Synonyms]
(S)-3-(Boc-aminomethyl)py...
(S)-tert-butyl pyrrolidin-3-ylmethylcarbamate
tert-butyl ((S)-pyrrolidin-3-yl)MethylcarbaMate
tert-butyl N-[(3S)-pyrrolidin-3-ylmethyl]carbamate
(S)-(3-Pyrrolidinylmethyl)-carbamic acid 1,1-dimethylethyl ester
Carbamic acid, N-[(3S)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester
Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD06796616 | [MOL File]
173340-26-6.mol | [Molecular Weight]
200.28 |
| Chemical Properties | Back Directory | [Boiling point ]
303.9±15.0 °C(Predicted) | [density ]
0.997 | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
12.71±0.46(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of (S)-3-N-Boc-aminomethylpyrrolidine from (3R)-1-[(1S)-1-phenylethyl]-3-pyrrolidinylmethyl]carbamic acid,1,1-dimethylethyl ester (9CI): tert-butyl [1-(1-phenylethyl)-pyrrolidin-3-ylmethyl]-carbamate (3.50 g, 11.5 mmol) was dissolved in methanol in methanol, 20% Pd/C catalyst was added and the hydrogenation reaction was carried out under hydrogen pressure of 50 psi.After 24 h, the reaction mixture was filtered and concentrated to afford 1.75 g (S)-3-N-Boc-aminomethylpyrrolidine (yield: 76%). Mass spectrometry analysis (APCI+): m/z 201 ([M+H]+). | [References]
[1] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 88; 89; 124
[2] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 116; 117; 152 |
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