| Identification | Back Directory | [Name]
Cloretazine | [CAS]
173424-77-6 | [Synonyms]
Cloretazine
1-[2-chloroethyl(methylsulfonyl)amino]-3-methyl-1-methylsulfonylurea
2-(2-chloroethyl)-N-methyl-1,2-bis(methylsulfonyl)hydrazinecarboxamide
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine
Methanesulfonic acid, 1-(2-chloroethyl)-2-[(methylamino)carbonyl]-2-(methylsulfonyl)hydrazide | [Molecular Formula]
C6H14ClN3O5S2 | [MDL Number]
MFCD00954061 | [MOL File]
173424-77-6.mol | [Molecular Weight]
307.78 |
| Hazard Information | Back Directory | [Uses]
Laromustine (VNP40101M) is a compound with antitumor activity. The mechanism of action of Laromustine mainly involves DNA alkylation and DNA repair inhibition. Laromustine can be used for bone marrow transplantation in patients with acute myeloid leukemia and cancer[1]. | [References]
[1] Nassar A E F, et al. An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes[J]. Drug metabolism and disposition, 2009, 37(9): 1922-1930. DOI:10.1124/dmd.109.027516 |
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