| Identification | Back Directory | [Name]
Cyclophosphamide-d4 | [CAS]
173547-45-0 | [Synonyms]
Cytoxan-d4
Endoxan-d4
Genoxal-d4
Mitoxan-d4
Hexadrin-d4
NSC 26271-d
NSC 26271-d4
Cyclostin-d4
Cycloblastin-d4
Cyclophosphamide-d4
N,N-Bis(2-chloroethyl)tetrahydro-4,5-d2-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide | [EINECS(EC#)]
244-379-2 | [Molecular Formula]
C7H15Cl2N2O2P | [MDL Number]
MFCD00144030 | [MOL File]
173547-45-0.mol | [Molecular Weight]
261.086 |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Solid | [Melting point ]
41-450C | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform: Slightly Soluble,Methanol: Slightly Soluble | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen. | [Description]
Cyclophosphamide-d4 contains four deuterium atoms. It is intended for use as an internal standard for the quantification of cyclophosphamide by GC- or LC-MS. Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders. In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug and is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death. | [References]
[1] MILLY E DE JONGE. Clinical pharmacokinetics of cyclophosphamide.[J]. Clinical Pharmacokinetics, 2005, 44 11: 1135-1164. DOI: 10.2165/00003088-200544110-00003
[2] W DENEVE. In vivo DNA cross-linking by cyclophosphamide: comparison of human chronic lymphatic leukemia cells with mouse L1210 leukemia and normal bone marrow cells.[J]. Cancer research, 1989, 49 13: 3452-3456.
[3] XIAO-HUI HUYAN. Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb/c mice[J]. International immunopharmacology, 2011, 11 9: Pages 1293-1297. DOI: 10.1016/j.intimp.2011.04.011
[4] CUNEYT CAGLAYAN. Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage.[J]. Environmental Science and Pollution Research, 2018, 25 21: 20968-20984. DOI: 10.1007/s11356-018-2242-5
[5] J. GIBSON B A B. Teratogenicity of structural truncates of cyclophosphamide in mice[J]. Teratology, 1971, 325 1: 141-150. DOI: 10.1002/tera.1420040205 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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