| Identification | Back Directory | [Name]
5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine | [CAS]
17375-63-2 | [Synonyms]
BGC 20-761
5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine | [Molecular Formula]
C19H22N2O | [MDL Number]
MFCD18384954 | [MOL File]
17375-63-2.mol | [Molecular Weight]
294.39 |
| Chemical Properties | Back Directory | [Boiling point ]
489.2±45.0 °C(Predicted) | [density ]
1.114±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
<14.72mg/ml in ethanol; <29.44mg/ml in DMSO | [form ]
solid | [pka]
16.74±0.30(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
BGC 20-761, is a selective high affinity 5-HT6 antagonist (Ki = 20 nM). that has shown to enhance memory consolidation in a rat model. It reverses he amnesic effects of Scopolamine (S200000). | [Biological Activity]
bgc20-761 is a selective and high affinity antagonist of 5-htc.the 5-ht6 receptor, a g protein-coupled receptor (gpcr), is a subtype of 5-ht receptor which binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-ht). this protein is expressed almost exclusively in the brain and mediates excitatory neurotransmission.in cellular level, bgc20-761 (5-methoxy-2-phenyl-n,n-dimethyltryptamine) was shown to selectively blocked 5-htc.bgc20-761 was used to study the difference in drug- induced effects in memory consolidation in young and mature rats and human. in young mice, bgc20-761 treatment at doses of 5 mg/kg and 10 mg/kg i.p, dose-dependently reversed a deficit of social recognition induced by scopolamine, an anticholinergic drug that impairs memory at dosage of 0.4 mg/kg i.p. in mature rats (6 months), recognition of the novel object was improved following administration of bgc20-761. the difference in effects of bgc20-761 in young vs. mature rats may reflect the status of memory consolidation in these different age ranges 1. | [in vivo]
BGC20-761 enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. BGC20-761 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; i.p.) alone has no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reverses a deficit of social recognition induced by Scopolamine (0.4 mg/kg i.p.)[1]. | Animal Model: | Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats[1] | | Dosage: | 2.5 mg/kg, 5 mg/kg and 10 mg/kg | | Administration: | Administered (i.p.) immediately after the training session for the social recognition test | | Result: | Administered alone did not show any difference in social recognition as compared to saline treated control animals.
However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition. |
| [IC 50]
Human 5-HT6 Receptor: 20 nM (Ki); Human 5-HT2A Receptor: 69 nM (Ki); Human D2 Receptor: 140 nM (Ki) | [storage]
Store at +4°C | [References]
1. mitchell es, hoplight bj, lear sp, et al. bgc20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-ht6 receptor-mediated mechanism. neuropharmacology. 2006;50(4):412-420. |
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BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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