| Identification | Back Directory | [Name]
Benzo[b]thiophene, 4-nitro-, 1,1-dioxide | [CAS]
17402-86-7 | [Synonyms]
PHGDH-IN-5
PHGDH-IN-5 (Compound B12)
Benzo[b]thiophene, 4-nitro-, 1,1-dioxide | [Molecular Formula]
C8H5NO4S | [MOL File]
17402-86-7.mol | [Molecular Weight]
211.19 |
| Hazard Information | Back Directory | [Uses]
PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells[1]. | [References]
[1] Cao XY, et al. Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors. Bioorg Chem. 2024;146:107330. DOI:10.1016/j.bioorg.2024.107330 |
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