| Identification | Back Directory | [Name]
Methoxy-PEG-propionicacid-N-succinimidylester | [CAS]
174569-25-6 | [Synonyms]
m-PEGn-NHS ester
m-PEG17-NHS ester
MPEGn-SPA 2K, 5K, 10K, 20K
Methyl-PEGn-NHS (n=12,13,24)
alpha-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-omega-methoxypoly(oxy-1,2-ethanediyl) | [Molecular Formula]
C80H155NO41 | [MDL Number]
MFCD06412227 | [MOL File]
174569-25-6.mol | [Molecular Weight]
1787.07 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
solid | [color ]
white to off-white | [α-end]
methoxy | [Ω-end]
NHS ester | [InChI]
InChI=1S/C10H15NO6/c1-15-6-7-16-5-4-10(14)17-11-8(12)2-3-9(11)13/h2-7H2,1H3 | [InChIKey]
IMSXKORGOVQCNT-UHFFFAOYSA-N | [SMILES]
O(N1C(CCC1=O)=O)C(=O)CCO{-}CC{+n}OC |
| Hazard Information | Back Directory | [Description]
m-PEG12-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reagent type: chemical modification reagent
reactivity: amine reactive | [IC 50]
PEGs | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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