| Identification | Back Directory | [Name]
L-759,633 | [CAS]
174627-50-0 | [Synonyms]
L 759
L-759
L-759,633
L759633,L-759633
(6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene
(6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
6H-Dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6aR,10aR)- | [Molecular Formula]
C26H40O2 | [MDL Number]
MFCD05662266 | [MOL File]
174627-50-0.mol | [Molecular Weight]
384.59 |
| Chemical Properties | Back Directory | [Boiling point ]
447.9±45.0 °C(Predicted) | [density ]
0.956±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Ethanol:20.0(Max Conc. mg/mL);52.0(Max Conc. mM)
PBS (pH 7.2):0.25(Max Conc. mg/mL);0.65(Max Conc. mM) | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
L-759,633 is a high-affinity peripheral cannabinoid receptor (CB2)-selective agonist with Ki values of 6.4 and 1,043 nM for CB2 and central cannabinoid (CB1) receptors, respectively. L-759,633 inhibits forskolin-stimulated cyclic AMP production in CHO cells transfected with CB2 or CB1 receptors with IC50 values of 8.1 nM and 10 μM, respectively. | [Uses]
L 759633 is a cannabinoid receptor (CB2) selective agonist and a structural analogues of ??9-Tetrahydro Cannabinol, an active constituent of cannabis. L 759633 has analgesic and anti-inflammatory properties. | [Definition]
ChEBI: 6h-dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6ar,10ar)- is a 1-benzopyran. | [Biological Activity]
High affinity, selective CB 2 receptor agonist (K i values are 6.4 and 1043 nM for CB 2 and CB 1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB 2 receptors expressed in CHO cells (EC 50 = 8.1 nM). | [IC 50]
CB2: 6.4 nM (Ki); CB1: 1043 nM (Ki) | [References]
[1] RUTH A ROSS. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630[J]. British Journal of Pharmacology, 2009, 126 3: 665-672. DOI: 10.1038/sj.bjp.0702351 |
|
|