| Identification | Back Directory | [Name]
TAS 103 | [CAS]
174634-08-3 | [Synonyms]
TAS 103
CS-1287
BMS-247615
TAS-103 HC1
TAS-103 base
TAS-103(salt)
TA103(bms-247615)
6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one
7H-Indeno[2,1-c]quinolin-7-one, 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy- | [Molecular Formula]
C20H19N3O2 | [MDL Number]
MFCD26960891 | [MOL File]
174634-08-3.mol | [Molecular Weight]
333.38 |
| Chemical Properties | Back Directory | [Melting point ]
216-217 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
589.5±50.0 °C(Predicted) | [density ]
1.350±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
7.88±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. | [Biological Activity]
TAS-103 is a dual DNA topoisomerase I/II (topoisomerase I/II) inhibitor for cancer research. | [in vivo]
TAS-103 (30 mg/kg, iv) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103. | [target]
| Topoisomerase I | Topoisomerase II | | [IC 50]
Topoisomerase I; Topoisomerase II | [storage]
Store at -20°C | [References]
[1] Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II DOI:10.1016/s0006-2952(00)00402-0
[2] Shimizu K, et al. Cancer chemotherapy by liposomal 6-[12-(dimethylamino)ethyl]aminol-3-hydroxy-7H-indeno[2,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. Biol Pharm Bull. 2002 Oct;25(10):1385-7. DOI:10.1248/bpb.25.1385
[3] Yoshida M, et al. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008 Mar;73(3):987-94. Epu DOI:10.1124/mol.107.043307 |
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SPIRO PHARMA
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Musechem
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Twochem Co.Ltd.
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Cckinase, Inc.
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