| Identification | Back Directory | [Name]
SB 218795 | [CAS]
174635-53-1 | [Synonyms]
SB 218795
Sb 218795r
methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate
(-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide
(-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE
(R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID
Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphar)- | [Molecular Formula]
C25H20N2O3 | [MDL Number]
MFCD00951240 | [MOL File]
174635-53-1.mol | [Molecular Weight]
396.44 |
| Chemical Properties | Back Directory | [Boiling point ]
623.7±55.0 °C(Predicted) | [density ]
1.237±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 40 mg/mL, soluble | [form ]
solid | [pka]
11.41±0.46(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
SB 218795 is an NK3 receptor antagonist. | [Definition]
ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines. | [Biological Activity]
Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction. | [in vivo]
SB 218795 (0.25-1 mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%[2]. | [IC 50]
hNK3: 13 nM (Ki); hNK2: 1220 nM (Ki) |
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