| Identification | Back Directory | [Name]
ginsenoside Rh(4) | [CAS]
174721-08-5 | [Synonyms]
ginsenoside Rh(4)
Ginsenoside Rh4, BR
ginsenoside Rh(4) USP/EP/BP
(3β,6α,12β,20E)-3,12-Dihydroxydammara-20(22),24-dien-6-yl β-D-glu copyranoside
β-D-Glucopyranoside, (3β,6α,12β,20E)-3,12-dihydroxydammara-20(22),24-dien-6-yl
(3beta,6alpha,12beta,20E)-3,12-Dihydroxydammara-20(22),24-dien-6-yl-beta-D-glucopyranoside | [Molecular Formula]
C36H60O8 | [MDL Number]
MFCD22125012 | [MOL File]
174721-08-5.mol | [Molecular Weight]
620.86 |
| Chemical Properties | Back Directory | [Melting point ]
>200°C (dec.) | [Boiling point ]
723.4±60.0 °C(Predicted) | [density ]
1.21 | [storage temp. ]
-20°C Freezer | [solubility ]
Methanol (Slightly), Pyridine (Slightly) | [form ]
Solid | [pka]
12.91±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginseng. | [Uses]
Ginsenoside Rh4 possesses inhibitory and antifungal activity. | [Definition]
ChEBI: Ginsenoside Rh4 is a triterpenoid saponin. | [in vivo]
To assess whether Ginsenoside Rh4 can inhibit the growth of colorectal cancer, a colorectal cancer xenograft model is established by inoculating nude mice with Caco-2 cells. Mice treated with 20 and 40 mg/kg Ginsenoside Rh4 and 40 mg/kg CAMPTO exhibit smaller tumors than the control after 30 days of treatment, showing inhibition rates of 29.91%, 66.30% and 77.82%, respectively. However, there is a significant difference in body weight between the Ginsenoside Rh4-treated group and the CAMPTO-treated group. The body weights of the 20 and 40 mg/kg Ginsenoside Rh4-treated groups (15.95±0.35 g and 18.35±0.44 g) are markedly higher, whereas the body weight of the CAMPTO-treated group is lower (10.85±0.28 g) than that of the solvent control group (14.19±0.25 g)[1]. | [target]
Caspase | Autophagy | Bcl-2/Bax | [IC 50]
Bax; Caspase 3; Caspase 8; Caspase 9; Apoptosis; Autophagy |
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