| Hazard Information | Back Directory | [Description]
5''-Deoxy-5''-methylthioadenosine-d3 (MTA-d3) is intended for use as an internal standard for the quantification of MTA by GC- or LC-MS. MTA is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases. | [Uses]
5''-(Methyl-d3-thio)adenosine (CAS# 174838-38-1) is a useful isotopically labeled research compound, where it is used in synthesis reactions. | [References]
[1] HUANG S. Histone methyltransferases, diet nutrients and tumour suppressors[J]. Nature Reviews Cancer, 2002, 2 6: 469-476. DOI: 10.1038/nrc819
[2] STEFAN KEHRAUS. Novel Amino Acid Derived Natural Products from the Ascidian Atriolum robustum: Identification and Pharmacological Characterization of a Unique Adenosine Derivative[J]. Journal of Medicinal Chemistry, 2004, 47 9: 2243-2255. DOI: 10.1021/jm031092g
[3] ADRIANA OLIVA. Studies on Substrate Specificity of S-Adenosylmethionine: Protein-Carboxyl Methyltransferase from Calf Brain[J]. The FEBS journal, 1980, 104 2: 595-602. DOI: 10.1111/j.1432-1033.1980.tb04463.x
[4] COLE P A. Chemical probes for histone-modifying enzymes[J]. Nature chemical biology, 2008, 4 10: 590-597. DOI: 10.1038/nchembio.111
[5] SUNG HO LEE Young D C. Induction of Apoptosis in Leukemia U937 Cells by 5′-Deoxy-5′-methylthioadenosine, a Potent Inhibitor of Protein Carboxylmethyltransferase[J]. Experimental cell research, 1998, 240 2: Pages 282-292. DOI: 10.1006/excr.1998.4000 |
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