| Identification | Back Directory | [Name]
2-(4-[(4-METHOXYBENZYL)OXY]PHENYL)ACETONITRILE | [CAS]
175135-47-4 | [Synonyms]
O411
O4I1
OSI1
OSI 1
OSI1;OSI 1
O4I1, >98%
4-(4-METHOXYBENZYLOXY)PHENYLACETONITRILE
2-(4-[(4-METHOXYBENZYL)OXY]PHENYL)ACETONITRILE
4-[(4-Methoxyphenyl)methoxy]benzeneacetonitrile
2-[4-[(4-methoxyphenyl)methoxy]phenyl]acetonitrile
Benzeneacetonitrile, 4-[(4-methoxyphenyl)methoxy]- | [Molecular Formula]
C16H15NO2 | [MDL Number]
MFCD00067778 | [MOL File]
175135-47-4.mol | [Molecular Weight]
253.3 |
| Chemical Properties | Back Directory | [Boiling point ]
424.5±30.0 °C(Predicted) | [density ]
1.129±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml; Ethanol: slightly | [form ]
A crystalline solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
O4I1 is an inducer of Oct3/4 expression and translation in diverse human cell lines (increases Oct3/4 mRNA in HEK293 cells by 2.5- and 4-fold at 10 and 20 μM, respectively). It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts. Through this action, O4I1 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts. | [Uses]
O4I1 is a potent Oct3/4 inducer. It promotes expression and stabilization of Oct3/4, and also enhanced its transcriptional activity in human somatic cells, making it useful in regenerative medicine. | [References]
[1] XINLAI CHENG. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers[J]. Journal of Medicinal Chemistry, 2015, 58 12: 4976-4983. DOI: 10.1021/acs.jmedchem.5b00144 |
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