| Identification | Back Directory | [Name]
CP 376395 | [CAS]
175140-00-8 | [Synonyms]
CP 376395
CP 376395 hydrochloride
CP376395;CP-376395;CP 376395
4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-
N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinaminehydrochloride | [Molecular Formula]
C21H30N2O | [MDL Number]
MFCD11519966 | [MOL File]
175140-00-8.mol | [Molecular Weight]
326.48 |
| Chemical Properties | Back Directory | [Melting point ]
224 °C | [Boiling point ]
434.9±45.0 °C(Predicted) | [density ]
1.018±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
DMF: 30 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml | [form ]
A crystalline solid | [pka]
7.23±0.48(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CP 376395 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2]. | [Biological Activity]
Potent and selective CRF 1 receptor antagonist (K i values are 12 and >10000 nM for CRF 1 and CRF 2 receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active. | [in vivo]
CP 376395 (10-20 mg/kg, i.p., Male B6 mice) attenuates H2O and food intake, increases sucrose intake, attenuates EtOH intake but not EtOH preference[2]. | Animal Model: | Male B6 mice (n=8-9 per group)[2] | | Dosage: | 0.0, 10.0, or 20.0 mg/kg | | Administration: | Intraperitoneally
| | Result: | Dose-dependently attenuated intake of H2O and food, with H2O intake affected specifically during the first half of the session. |
| [IC 50]
CRFR1; CRFR2 | [References]
[1] Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92. DOI:10.1021/jm070579c
[2] Giardino WJ, et al. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol Clin Exp Res. 2013 Jul;37(7):1161-70. DOI:10.1111/acer.12076 |
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