| Identification | Back Directory | [Name]
2,6-dichloro-N-Methylpyridin-4-aMine | [CAS]
175461-33-3 | [Synonyms]
2,6-dichloro-4-methylamino-pyridine
2,6-dichloro-N-Methylpyridin-4-aMine
2,6-dichloro-N-methyl-4-Pyridinamine
4-Pyridinamine, 2,6-dichloro-N-methyl- | [Molecular Formula]
C6H6Cl2N2 | [MDL Number]
MFCD12024871 | [MOL File]
175461-33-3.mol | [Molecular Weight]
177.03 |
| Chemical Properties | Back Directory | [Melting point ]
70 °C | [Boiling point ]
312.0±37.0 °C(Predicted) | [density ]
1.404±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
0.79±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: 2,4,6-Trichloropyridine (20.0 g, 109.63 mmol) was dissolved in anhydrous ethanol (100 mL). An ethanol solution of 33% methylamine (81.9 mL, 657 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred continuously at room temperature for 2 weeks. After completion of the reaction, the white precipitate was collected by filtration and washed with methyl tert-butyl ether and deionized water sequentially to afford 2,6-dichloro-4-methylaminopyridine (11.9 g, 61% yield) as white crystals. | [References]
[1] Patent: WO2008/92942, 2008, A2. Location in patent: Page/Page column 22
[2] Patent: WO2006/53166, 2006, A1. Location in patent: Page/Page column 57-58
[3] New Journal of Chemistry, 2016, vol. 40, # 11, p. 9194 - 9204
[4] Patent: WO2006/122137, 2006, A1. Location in patent: Page/Page column 71-72
[5] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0300; 0331; 0551; 0552 |
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