| Identification | Back Directory | [Name]
L-Tyrosine, L-leucylglycyl-L-glutaminyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-prolyl- | [CAS]
176326-01-5 | [Synonyms]
Gliadin p31-43
L-Tyrosine, L-leucylglycyl-L-glutaminyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-prolyl- | [Molecular Formula]
C71H102N18O20 | [MOL File]
176326-01-5.mol | [Molecular Weight]
1527.68 |
| Chemical Properties | Back Directory | [Boiling point ]
1968.7±65.0 °C(Predicted) | [density ]
1.371±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.11±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Gliadin p31-43 is an undigested gliadin peptide. Gliadin p31-43 induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 can be used for celiac disease research[1][2]. | [in vivo]
Gliadin p31-43 (10 μg; intraluminally injection) shows a sequence-specific spontaneous ability to form structured oligomers and aggregates in vitro and induced activation of the apoptosis-associated speck-like (ASC) complex[2].
The increment of IL-1β indicates the activation of the inflammasome caspase-1 pathway in the small intestine mucosa by oral administration of Gliadin p31-43 (20 μg) in wild type C57Bl/6 mice. Gliadin p31-43 has an intrinsic propensity to form oligomers which trigger the NLRP3 inflammasome[2]. | [References]
[1] Merlin Nanayakkara, et al. P31-43, an undigested gliadin peptide, mimics and enhances the innate immune response to viruses and interferes with endocytic trafficking: a role in celiac disease. Sci Rep. 2018 Jul 17;8(1):10821. DOI:10.1038/s41598-018-28830-y
[2] María Florencia Gómez Castro, et al. p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine. Front Immunol. 2019 Jan 30;10:31. DOI:10.3389/fimmu.2019.00031 |
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