| Identification | Back Directory | [Name]
8-ISO PROSTAGLANDIN F2BETA | [CAS]
177020-26-7 | [Synonyms]
8-ISO-9BETA-PGF2ALPHA
8-iso Prostaglandin F2β
8-ISO PROSTAGLANDIN F2BETA
8-isoprostaglandin PGF2beta
PXGPLTODNUVGFL-HMALSPAFSA-N
9BETA,11ALPHA,15S-TRIHYDROXY-(8BETA)-PROSTA-5Z,13E-DIEN-1-OIC ACID
9alpha,11alpha,15S-trihydroxy-(8beta)-prost-5Z,13E-dien-1-oic-acid
(Z)-7-[(1S,2R,3R,5R)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid | [Molecular Formula]
C20H34O5 | [MDL Number]
MFCD00216066 | [MOL File]
177020-26-7.mol | [Molecular Weight]
354.48 |
| Chemical Properties | Back Directory | [Boiling point ]
531.0±50.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [solubility ]
10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a) | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α | [Uses]
8-iso Prostaglandin F2β (8-iso PGF2β) is a biomarker for assessing oxidative stress, and its content in serum can indirectly reflect the level of oxidative stress[1]. | [References]
[1] Shaker S R, Al-Amran F, Fatima G, et al. Trimetazidine improves the outcome of EECP therapy in patients with refractory angina pectoris[J]. Medical Archives, 2020, 74(3): 199. |
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