| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxylic acid, 3-(1-methylethyl)-1-propyl-5-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- | [CAS]
177847-28-8 | [Synonyms]
UR7247
UR-7247
UR 7247
1H-Pyrazole-4-carboxylic acid, 3-(1-methylethyl)-1-propyl-5-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- | [Molecular Formula]
C24H26N6O2 | [MOL File]
177847-28-8.mol | [Molecular Weight]
430.5 |
| Hazard Information | Back Directory | [Description]
UR-7247 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. UR-7247 has a very long plasma elimination half-life, which may be due to a high but also tight binding to protein binding sites. | [Uses]
UR-7247 is a potent and orally active angiotensin II AT1 receptor antagonist. UR-7247 decreases arterial pressure and increases renal blood flow[1][2]. | [IC 50]
AT1 Receptor | [References]
[1] Maillard MP, et al. Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6. J Cardiovasc Pharmacol. 2000 Mar;35(3):383-9. DOI:10.1097/00005344-200003000-00006
[2] Alexander Scriabine, et al. New Cardiovascular Drugs, XIIIth International Congress of Pharmacology, Munich, Germany, July 26-31, 1998. 16(3):312-317. |
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