| Identification | Back Directory | [Name]
3-(2-ETHYLPHENYL)-2-MERCAPTOQUINAZOLIN-4(3H)-ONE | [CAS]
177951-34-7 | [Synonyms]
Thioxodihydroquinazolinone19
Thioxodihydroquinazolinone-19
Thioxodihydroquinazolinone 19
3-(2-ETHYLPHENYL)-2-MERCAPTOQUINAZOLIN-4(3H)-ONE
3-(2-ethylphenyl)-2-sulfanylidene-1H-quinazolin-4-one
3-(2-Ethylphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
4(1H)-Quinazolinone, 3-(2-ethylphenyl)-2,3-dihydro-2-thioxo- | [Molecular Formula]
C16H14N2OS | [MDL Number]
MFCD01313715 | [MOL File]
177951-34-7.mol | [Molecular Weight]
282.36 |
| Hazard Information | Back Directory | [Description]
Thioxodihydroquinazolinone-19 is an inducer of apoptotic cell death in platinum-resistant A2780cis human ovarian cancer cells. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisplatin. | [Uses]
Anticancer agent 173 (compound 19) is a potent thioxodihydroquinazolinone analogs when combined with platinum drugs in inducing apoptotic cancer cells death[1]. | [References]
[1] Jing Ma, et al. Combination of a thioxodihydroquinazolinone with cisplatineliminates ovarian cancer stem cell-like cells (CSC-LCs) andshows preclinical potential. Oncotarget. 2017 Dec 26;9(5):6042-6054. DOI:10.18632/oncotarget.23679 |
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| Company Name: |
Enamine
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| Tel: |
(380) 44 537 32 18 |
| Website: |
www.enamine.net |
| Company Name: |
Interchim S.A.
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| Tel: |
(33) 4 70 03 88 55 |
| Website: |
www.interchim.com |
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