| Identification | Back Directory | [Name]
2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine | [CAS]
177980-10-8 | [Synonyms]
2'-Azido-2'-deoxy-5'-O-DMT-uridine
2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine | [Molecular Formula]
C30H29N5O7 | [MOL File]
177980-10-8.mol | [Molecular Weight]
571.59 |
| Hazard Information | Back Directory | [Uses]
2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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