| Identification | Back Directory | [Name]
1H-Imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione, 6-[(4-fluorophenyl)methyl]-5,6,11,11a-tetrahydro- | [CAS]
1781233-72-4 | [Synonyms]
1H-Imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione, 6-[(4-fluorophenyl)methyl]-5,6,11,11a-tetrahydro- | [Molecular Formula]
C20H16FN3O2 | [MOL File]
1781233-72-4.mol | [Molecular Weight]
349.36 |
| Hazard Information | Back Directory | [Description]
PAT-494 is a type II Autotaxin inhibitor. | [Uses]
(Rac)-PAT-494 is a type II autotaxin inhibitor with the activity of inhibiting the production of lysophosphatidic acid (LPA) in the blood. (Rac)-PAT-494 can participate in the inhibition of diseases related to cancer, fibrosis and inflammation by antagonizing the function of autotaxin. (Rac)-PAT-494 shows high activity in biochemical and plasma tests. (Rac)-PAT-494 can reduce plasma LPA levels after oral administration to rats[1]. | [References]
[1] Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors |
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