| Hazard Information | Back Directory | [Description]
RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 9 pM). It is competitive with W146 , a selective S1P1 antagonist, and induces internalization and polyubiquitination of S1P1 in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg). It reduces S1P1-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1eGFP/eGFP mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis. | [Uses]
RP 001 Hydrochloride is a picomolar, short-acting S1P1 agonist. | [in vivo]
RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1]. | [storage]
Store at -20°C |
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