| Identification | Back Directory | [Name]
Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:2) | [CAS]
1781932-33-9 | [Synonyms]
BMS-599626 2HCL(714971-09-2 Free base)
BMS-599626 2HCL(714971-09-2 Free base), 10 mM in DMSO
Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:2) | [Molecular Formula]
C27H28ClFN8O3 | [MOL File]
1781932-33-9.mol | [Molecular Weight]
567.02 |
| Hazard Information | Back Directory | [Uses]
BMS-599626 dihydrochloride is a small molecule pan-HER (human epidermal growth factor receptor) kinase inhibitor. BMS-599626 dihydrochloride primarily targets HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activity in the HER family. BMS-599626 inhibits the kinase activity of HER1 and HER2 by competing with their ATP-binding sites, and can inhibit the downstream signaling pathway by blocking the heterodimer formation of HER1 and HER2. BMS-599626 dihydrochloride can be used to study the antitumor effects of multiple HER1 or HER2 overexpressed tumor models[1]. | [IC 50]
HER1: 20 nM (IC50); HER2: 30 nM (IC50) | [References]
[1] Wong T W, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling[J]. Clinical cancer research, 2006, 12(20): 6186-6193. DOI:10.1158/1078-0432.CCR-06-0642 |
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