| Identification | Back Directory | [Name]
NOCICEPTIN (1-7) | [CAS]
178249-42-8 | [Synonyms]
NOCICEPTIN (1-7)
Nociceptin Fragment 1-7
Orphanin FQ Fragment 1-7 | [Molecular Formula]
C31H41N7O9 | [MDL Number]
MFCD02684529 | [MOL File]
178249-42-8.mol | [Molecular Weight]
655.7 |
| Chemical Properties | Back Directory | [Boiling point ]
1193.6±65.0 °C(Predicted) | [density ]
1.319±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
Powder | [pka]
3.42±0.10(Predicted) | [Water Solubility ]
Soluble to 2 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
Nociceptin (1-7), also known as orphanin FQ, is identified as naturally occurring agonist of orphan opioid receptor-like ORL1 receptor. | [in vivo]
Nociceptin (1-7) (intrathecal injection; 150–1200? nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0?fmol), nociceptin-induced hyperalgesia is significantly reduced[1]. | Animal Model: | Mice[1] | | Dosage: | 150–1200? nmol | | Administration: | Intrathecal injection; single dose | | Result: | Co-treatment with nociceptin could reduce hyperalgesia. |
| [IC 50]
NOP Receptor/ORL1 |
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