| Chemical Properties | Back Directory | [Boiling point ]
693.1±55.0 °C(Predicted) | [density ]
1.135±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
EtOH/H2O (95:5): 2 mg/ml; DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml | [form ]
Liquid | [pka]
2.05±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ) in macrophages.1,2 DHA is oxidized to maresin 1 (MaR1; ), which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase, then to MCTR2 by γ-glutamyl transferase, and to MCTR3 by dipeptidase.3 MCTR3 accelerates tissue regeneration in planaria (1 and 100 nM) approximately as potently as MCTR2 and more potently than MCTR1.2 Pretreatment with MCTR3 prior to E. coli administration in mice reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR3 selectively reduces the amount of the eicosanoids PGD2 , PGE2 , PGF2α , and TXB2 in the exudate. | [Uses]
MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis[1][2][3]. | [in vivo]
MCTR3 (2 ng/g, i.p., single dose) reduces inflammation and oxidative response in the LPS-induced acute lung injury and decreases the apoptosis in C57BL/6 mice[1].
MCTR3 (1-100 nM, in cold water) stimulates tissue regeneration in surgical injuried Planaria in a dose-dependent manner with a 50% tissue regeneration TRI50 of 2.5 days[2]. | Animal Model: | Lipopolysaccharide induced acute lung injury in C57BL6 mice[1] | | Dosage: | 2 ng/g | | Administration: | i.p., single dose | | Result: | Reduced inflammatory cell infiltration and protein accumulation in bronchoalveolar lavage fluid (BALF), reduced MDA levels and increased SOD activity in lung tissue.
Decreased levels of pro-inflammatory cytokine in serum. |
| Animal Model: | Surgical injury in Planaria[2] | | Dosage: | 1-100 nM | | Administration: | In cold water for 6 days | | Result: | Accelerated tissue regeneration in a dose-dependent manner with a TRI50 of 2.5 days. |
| [storage]
Store at -20°C | [References]
1. Serhan, C.N. Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology Nature 510(7503),92-101(2014).
2. Dalli, K.J., Sanger, J.M., Rodriguez, A.R., et al. Identification and actions of a novel third maresin conjugate in tissue regeneration: MCTR3 PLoS One 11(2),e0149319(2016).
3. Dalli, J., Vlasakov, I., Riley, I.R., et al. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. USA 113(43),12232-12237(2016). |
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