| Identification | Back Directory | [Name]
TA-01 | [CAS]
1784751-18-3 | [Synonyms]
TA-01
TA-01;TA01;TA 01
Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]- | [Molecular Formula]
C20H12F3N3 | [MDL Number]
MFCD30182287 | [MOL File]
1784751-18-3.mol | [Molecular Weight]
351.32 |
| Chemical Properties | Back Directory | [Boiling point ]
511.1±50.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml; DMSO: 3 mg/ml | [form ]
A crystalline solid | [pka]
9.26±0.24(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity. | [Uses]
TA 01 induces cardiomyocyte differentiation of pluripotent stem cells. | [IC 50]
CKIδ: 6.8 nM (IC50); p38 MAP kinase: 6.7 nM (IC50) | [References]
[1] FILIP LACO . Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling[J]. Journal of molecular and cellular cardiology, 2015, 80: Pages 56-70. DOI: 10.1016/j.yjmcc.2014.12.003 |
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| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
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