| Hazard Information | Back Directory | [Description]
KF24345 is an adenosine uptake inhibitor. | [Uses]
KF24345 free base is an orally active adenosine uptake inhibitor. KF24345 free base inhibits adenosine uptake by human, mouse, rabbit and hamster erythrocytes with IC50 values of 59.5, 130.1, 104.2 and 30.9 nM, respectively. KF24345 free base has anti-inflammatory activity and can inhibit LPS-induced TNF-α production and leukopenia in mice[1]. | [References]
[1] Noji T, et al. KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-α production and leukopenia via endogenous adenosine in mice[J]. Journal of Pharmacology and Experimental Therapeutics, 2002, 300(1): 200-205. DOI:10.1124/jpet.300.1.200 |
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