| Identification | Back Directory | [Name]
2H-1,4-Benzoxazine-2-carboxamide, 3,4-dihydro-N-[(1S,2S)-2-hydroxycyclohexyl]-4-[[4-(1H-pyrazol-1-yl)phenyl]methyl]-, (2R)- | [CAS]
1788055-11-7 | [Synonyms]
VU0486846
2H-1,4-Benzoxazine-2-carboxamide, 3,4-dihydro-N-[(1S,2S)-2-hydroxycyclohexyl]-4-[[4-(1H-pyrazol-1-yl)phenyl]methyl]-, (2R)- | [Molecular Formula]
C25H28N4O3 | [MOL File]
1788055-11-7.mol | [Molecular Weight]
432.51 |
| Hazard Information | Back Directory | [Description]
VU0486846 is a highly selective M1 positive allosteric modulator (PAM). | [Uses]
VU0486846 is an orally active and selective muscarinic acetylcholine receptor M1 positive allosteric modulator (PAM) [1]. | [References]
[1] Bertron JL, et al. The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2175-2179. DOI:10.1016/j.bmcl.2018.05.009 |
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| Company Name: |
Merck KGaA
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21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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