| Identification | Back Directory | [Name]
TIPLIMOTIDE | [CAS]
178823-49-9 | [Synonyms]
TIPLIMOTIDE
L-Proline, D-alanyl-L-lysyl-L-prolyl-L-valyl-L-valyl-L-histidyl-L-leucyl-L-phenylalanyl-L-alanyl-L-asparaginyl-L-isoleucyl-L-valyl-L-threonyl-L-prolyl-L-arginyl-L-threonyl- | [Molecular Formula]
C87H142N24O21 | [MDL Number]
MFCD09837784 | [MOL File]
178823-49-9.mol | [Molecular Weight]
1860.21 |
| Hazard Information | Back Directory | [Uses]
Tiplimotide (NBI-5788) is an altered peptide ligand (APL) designed from an immunodominant region (83-99) of the neuroantigen myelin basic protein (MBP). Tiplimotide can selectively reduce the production of inflammatory cytokines by pathogenic T-cells. Tiplimotide can be used for the research of multiple sclerosis (MS)[1][2]. | [References]
[1] P D Crowe, et al. NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. Ann Neurol. 2000 Nov;48(5):758-65. PMID:11079539
[2] Maria Katsara, et al. A double mutation of MBP(83-99) peptide induces IL-4 responses and antagonizes IFN-gamma responses. J Neuroimmunol. 2008 Aug 30;200(1-2):77-89. DOI:10.1016/j.jneuroim.2008.06.013 |
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YantaiBio
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13758194781; 13758194781 |
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Fuan Bio
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15002819872 |
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fuanbio.com |
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