| Identification | Back Directory | [Name]
TiMcodar | [CAS]
179033-51-3 | [Synonyms]
VX 853
VX-853
TiMcodar
Timcodar ,VX-853
TimcodarQ: What is
Timcodar Q: What is the CAS Number of
Timcodar
(2S)-N-benzyl-3-(4-chlorophenyl)-N-(1,5-dipyridin-4-ylpentan-3-yl)-2-[methyl-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]amino]propanamide
Benzenepropanamide, 4-chloro-α-[methyl[2-(3,4,5-trimethoxyphenyl)-2-oxoacetyl]amino]-N-(phenylmethyl)-N-[3-(4-pyridinyl)-1-[2-(4-pyridinyl)ethyl]propyl]-, (αS)- | [Molecular Formula]
C43H45ClN4O6 | [MDL Number]
MFCD00948808 | [MOL File]
179033-51-3.mol | [Molecular Weight]
749.29 |
| Hazard Information | Back Directory | [Uses]
Timcodar is a macrolide agent, and studies have shown that during adipogenesis, timcodar can significantly inhibit fat accumulation, with an effect similar to that of rapamycin. However, unlike rapamycin, timcodar does not cause immunosuppression and glucose resistance. In addition, timcodar can effectively inhibit the adipogenic transcriptional regulators PPAR?? and C/EBP??, thereby inhibiting genes involved in fat accumulation. These studies lay the foundation for timcodar as a potential anti-obesity therapy, as obesity is becoming a global epidemic. | [References]
[1] Timcodar (VX‐853) Is a Non‐FKBP12 Binding Macrolide Derivative That Inhibits PPARγ and Suppresses Adipogenesis |
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