| Identification | Back Directory | [Name]
FLICE | [CAS]
179241-78-2 | [Synonyms]
MCH5
MACH
MASH
CAP4
MCH51
FLICE
MACH2
FLICE3
MACH-1
ALPS2B
CASPASE-8
HUMAN CASPASE-8
CASPASE-8, HUMAN
FLICE, ACTIVE FORM
Caspase-8 precursor
CASPASE-8, ACTIVE FORM
Apoptotic protease Mch-5
Apoptotic cysteine protease
CASPASE-8 (HUMAN) (RECOMBINANT)
CASPASE-8 (HUMAN) (ACTIVE) (REC)
CASPASE-8, HUMAN, RECOMBINANT, E COLI
CASPASE-8 (HUMAN) (ACTIVE) (RECOMBINANT)
FADD-homologous ICE/CED-3- like protease
CASPASE-8 PROTEIN, RECOMBINANT HUMAN ACTIVE
Monoclonal Anti-CASP8 antibody produced in mouse
Anti-CASP8 (Cleaved-Asp384), C-Terminal antibody produced in rabbit | [MDL Number]
MFCD01865996 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T | [Risk Statements ]
36/37/38-61 | [Safety Statements ]
26-36-45-53 | [WGK Germany ]
2 | [Storage Class]
6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | [Hazard Classifications]
Eye Irrit. 2
Repr. 1B
Skin Irrit. 2
Skin Sens. 1 |
| Hazard Information | Back Directory | [Uses]
Human recombinant C−terminal histidine tagged caspase 8 is expressed as the truncated pro-caspase 8 (amino acids 213−496). It is a fully active protein consisting of 18 kDa and 12.4 kDa subunits; the 12.4 kDa subunit contains the histidine tag. | [General Description]
Human recombinant C?terminal histidine tagged caspase 8 is expressed as the truncated pro-caspase 8 (amino acids 213?496). It is a fully active protein consisting of 18 kDa and 12.4 kDa subunits; the 12.4 kDa subunit contains the histidine tag. | [Biochem/physiol Actions]
Caspase 8 is at the top of the hierarchy of the caspase cascade and is considered an initiator caspase. It exists in the cell as an inactive 55?kDa proenzyme. It is converted to the active form, consisting of 18?kDa and 11?kDa subunits, upon its recruitment to the cytoplasmic domain of activated death receptors such as CD95 or TNFR via the adapter protein FADD. The activation of the proenzyme is triggered by the protein′s aggregation, which leads to auto- or transprocessing. Caspase?8 activates downstream caspases (caspases?3, 6, and 7) that cleave key cellular substrates and lead to apoptotic death of the cells. |
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