| Identification | Back Directory | [Name]
R 093877 | [CAS]
179474-80-7 | [Synonyms]
R 93877
Prucalopride HCl
Prucalopride hydrochloride
Prucalopride HCl (R-108512, R-93877)
4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide:hydrochloride | [Molecular Formula]
C18H27Cl2N3O3 | [MDL Number]
MFCD00948730 | [MOL File]
179474-80-7.mol | [Molecular Weight]
404.33 |
| Hazard Information | Back Directory | [Uses]
Prucalopride hydrochloride is an orally active, selective and specific 5-HT4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride hydrochloride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride hydrochloride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride hydrochloride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3]. | [References]
[1] Chen M, et al. Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway. Hum Exp Toxicol. 2020 Feb;39(2):173-181. DOI:10.1177/0960327119883409
[2] Wang Y, et al. Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats. Int J Mol Med. 2022 Jul;50(1):87. DOI:10.3892/ijmm.2022.5143
[3] Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83. DOI:10.1016/s0014-2999(01)01087-1 |
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