| Identification | Back Directory | [Name]
Methanone, [4-[4-(3-amino-1H-indazol-4-yl)benzoyl]-1-piperazinyl](2,4-dichlorophenyl)- | [CAS]
1795736-60-5 | [Synonyms]
BCR-ABL-IN-5
Methanone, [4-[4-(3-amino-1H-indazol-4-yl)benzoyl]-1-piperazinyl](2,4-dichlorophenyl)- | [Molecular Formula]
C25H21Cl2N5O2 | [MOL File]
1795736-60-5.mol | [Molecular Weight]
494.37 |
| Hazard Information | Back Directory | [Uses]
BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells[1]. | [References]
[1] Ashraf K El-Damasy, et al. Design, synthesis, and biological evaluations of novel 3-amino-4-ethynyl indazole derivatives as Bcr-Abl kinase inhibitors with potent cellular antileukemic activity. Eur J Med Chem. 2020 Dec 1;207:112710. DOI:10.1016/j.ejmech.2020.112710 |
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