| Identification | Back Directory | [Name]
β-Apo-13-carotenone | [CAS]
17974-57-1 | [Synonyms]
D'Orenone
β-Apo-13-carotenone
3,5,7-Octatrien-2-one, 6-methyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (3E,5E,7E)- | [Molecular Formula]
C18H26O | [MDL Number]
MFCD31544340 | [MOL File]
17974-57-1.mol | [Molecular Weight]
258.4 |
| Chemical Properties | Back Directory | [Boiling point ]
120 °C(Press: 0.0004 Torr) | [density ]
0.945±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 33.33 mg/mL (128.99 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Oil | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα. | [Definition]
ChEBI: 13-apo-beta-carotenone is an apo carotenoid compound arising from oxidative degradation of the beta,beta-carotene skeleton at the 13-position. It is an apo carotenoid and an enone. | [References]
[1] Eroglu A, et al. The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα. Arch Biochem Biophys. 2010 Dec 1;504(1):11-6. DOI:10.1016/j.abb.2010.07.025
[2] Sun J, et al. β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor. J Biol Chem. 2014 Nov 28;289(48):33118-24. DOI:10.1074/jbc.M114.610501
[3] Wang CX, et al. Actions of β-apo-carotenoids in differentiating cells: differential effects in P19 cells and 3T3-L1 adipocytes. Arch Biochem Biophys. 2015 Apr 15;572:2-10. DOI:10.1016/j.abb.2015.01.009 |
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