| Identification | Back Directory | [Name]
DMEA-PNU-159682 | [CAS]
1799421-48-9 | [Synonyms]
DMEA-PNU-159682
Carbamic acid, N-methyl-N-[2-(methylamino)ethyl]-, 2-[(2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-4-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4',3':4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-6,11-dioxo-2-naphthacenyl]-2-oxoethyl ester | [Molecular Formula]
C37H45N3O14 | [MDL Number]
MFCD32263026 | [MOL File]
1799421-48-9.mol | [Molecular Weight]
755.76 |
| Hazard Information | Back Directory | [Uses]
DMEA-PNU-159682 (molecule D12) is a ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682[1][2]. | [IC 50]
Daunorubicins/Doxorubicins | [References]
[1] Chen Jingkang, et al. Disubstituted maleic amide class connexon for antibody-drug conjugate and its preparation method and application. CN108101825A.
[2] John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1 |
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