| Identification | Back Directory | [Name]
dFKBP-1 | [CAS]
1799711-22-0 | [Synonyms]
dFKBP-1
2-Piperidinecarboxylic acid, 1-(3,3-dimethyl-1,2-dioxopentyl)-, (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[[4-[[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]amino]-1,4-dioxobutyl]amino]phenyl]propyl ester, (2S)- | [Molecular Formula]
C53H64N6O14 | [MDL Number]
MFCD32701898 | [MOL File]
1799711-22-0.mol | [Molecular Weight]
1009.11 |
| Hazard Information | Back Directory | [Uses]
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF (HY-114872) of FKBP12, the Thalidomide based Cereblon ligand and a linker[1]. | [IC 50]
Cereblon; FKBP | [References]
[1] Winter GE, et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348(6241):1376-81. DOI:10.1126/science.aab1433 |
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