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1799788-94-5

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1799788-94-5 Structure

1799788-94-5 Structure
IdentificationBack Directory
[Name]

PF-06683324
[CAS]

1799788-94-5
[Synonyms]

Trk-IN-4
PF-06683324
PF-06683324 >=98% (HPLC)
[Molecular Formula]

C24H23F4N5O4
[MDL Number]

MFCD30480908
[MOL File]

1799788-94-5.mol
[Molecular Weight]

521.46
Chemical PropertiesBack Directory
[Boiling point ]

696.8±55.0 °C(Predicted)
[density ]

1.46±0.1 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMSO: 30mg/mL, clear
[form ]

powder
[pka]

14.02±0.50(Predicted)
[color ]

white to beige
[InChIKey]

XJIIVPVOGYFVME-QUCCMNQESA-N
[SMILES]

O=C(CC1=CC=C(OC(F)(F)F)C=C1)N2C[C@@H](F)[C@@H](OC3=C(C(N)=O)C=C(C4=CN(C)C=N4)C=N3)CC2
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P305+P351+P338
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard InformationBack Directory
[Uses]

PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
[Biological Activity]

PF-0668324 is pan tropomyosin-related kinase (Trk) inhibitor.
[IC 50]

TrkA: 1.9 nM (IC50, in cell-based assays); TrkB: 2.6 nM (IC50, in cell-based assays); TrkC: 1.1 nM (IC50, in cell-based assays)
[storage]

Store at -20°C
[References]

[1] Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. DOI:10.1021/acs.jmedchem.8b00633
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