| Identification | Back Directory | [Name]
PF-06683324 | [CAS]
1799788-94-5 | [Synonyms]
Trk-IN-4
PF-06683324
PF-06683324 >=98% (HPLC) | [Molecular Formula]
C24H23F4N5O4 | [MDL Number]
MFCD30480908 | [MOL File]
1799788-94-5.mol | [Molecular Weight]
521.46 |
| Chemical Properties | Back Directory | [Boiling point ]
696.8±55.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 30mg/mL, clear | [form ]
powder | [pka]
14.02±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with
IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. | [Biological Activity]
PF-0668324 is pan tropomyosin-related kinase (Trk) inhibitor. | [IC 50]
TrkA: 1.9 nM (IC50, in cell-based assays); TrkB: 2.6 nM (IC50, in cell-based assays); TrkC: 1.1 nM (IC50, in cell-based assays) | [storage]
Store at -20°C | [References]
[1] Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. DOI:10.1021/acs.jmedchem.8b00633 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|