| Identification | Back Directory | [Name]
E-7386 | [CAS]
1799824-08-0 | [Synonyms]
E-7386,Epigenetic Reader Domain,E 7386,inhibit,Inhibitor
2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, 8-[[6-[3-(4-ethyl-1-piperazinyl)-1-azetidinyl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]hexahydro-4,7-dioxo-N-(phenylmethyl)-2-(2-propen-1-yl)-, (6S,9aS)- | [Molecular Formula]
C39H48FN9O4 | [MOL File]
1799824-08-0.mol | [Molecular Weight]
725.85 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:125.0(Max Conc. mg/mL);172.21(Max Conc. mM) | [form ]
Solid | [pka]
8.92±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
E-7386, is an CBP/beta-catenin modulator that is shown to be orally active. E-7386, has shown high antitumor activity in Wnt1 model. | [in vivo]
E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group[1]. | [storage]
Store at -20°C |
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