| Identification | Back Directory | [Name]
H-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 | [CAS]
179986-95-9 | [Synonyms]
Human[Leu31,Pro34]peptide YY
H-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 | [Molecular Formula]
C195H296N54O56 | [MDL Number]
MFCD00678656 | [MOL File]
179986-95-9.mol | [Molecular Weight]
4292.76 |
| Chemical Properties | Back Directory | [form ]
Powder | [Sequence]
Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 | [InChIKey]
RBHVYOZPGFYUBN-YNVORAAPSA-N |
| Hazard Information | Back Directory | [Uses]
(Leu31,Pro34)-Peptide YY (human) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM[1]. | [in vivo]
(Leu31,Pro34)-Peptide YY (0.1-1 nmol/day; ICV; 14 days) displays anxiolytic and antidepressant effect in rats[2]. | Animal Model: | Male Sprague Dawley rats weighing 150-170 g, OBX/Sham model[2] | | Dosage: | 0.1, 0.3 and 1 nmol/day | | Administration: | ICV, for 14 days | | Result: | Significantly decreased hyperlocomotion and immobility time in OBX animals. Reversed the deficit in social contacts in OBX animals. Reduced grooming behavior in sham animals.
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| [IC 50]
NPY Y1 receptor: 1.0 nM (Kd); NPY Y2 receptor: 670 nM (Kd) | [References]
[1] Dumont Y, et al. Peptide YY derivatives as selective neuropeptide Y/peptide YY Y1 and Y2 agonists devoided of activity for the Y3 receptor sub-type. Brain Res Mol Brain Res. 1994 Oct;26(1-2):320-4. DOI:10.1016/0169-328x(94)90105-8
[2] Morales-Medina JC, et al. Role of neuropeptide Y Y? and Y? receptors on behavioral despair in a rat model of depression with co-morbid anxiety. Neuropharmacology. 2012 Jan;62(1):200-8. DOI:10.1016/j.neuropharm.2011.06.030 |
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