| Identification | Back Directory | [Name]
DHODH-IN-1 | [CAS]
1800296-63-2 | [Synonyms]
DHODH-IN-1
DHODHIN1,DHODH IN 1
Pyridine, 5-cyclopropyl-2-[4-(2,6-difluorophenoxy)-5-methyl-3-(1-methylethoxy)-1H-pyrazol-1-yl]-3-fluoro- | [Molecular Formula]
C21H20F3N3O2 | [MDL Number]
MFCD34469754 | [MOL File]
1800296-63-2.mol | [Molecular Weight]
403.4 |
| Chemical Properties | Back Directory | [Boiling point ]
439.8±45.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-1.66±0.19(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway[1]. | [in vivo]
DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min[1].
| [References]
[1] Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98. DOI:10.1021/acs.jmedchem.5b00606 |
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