| Identification | Back Directory | [Name]
CDK4/6-IN-2 | [CAS]
1800506-48-2 | [Synonyms]
AM24679P4
CDK4/6-IN-2
CDK4/6 inhibitor 2
Cyclin dependent kinase,CDK-4/6-IN-2,CDK,CDK4/6 IN 2,CDK4/6IN2,inhibit,Inhibitor
5-((4-ethylpiperazin-1-yl)methyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)pyrimidin-2-amine | [Molecular Formula]
C27H32F2N8 | [MDL Number]
MFCD32067908 | [MOL File]
1800506-48-2.mol | [Molecular Weight]
506.59 |
| Chemical Properties | Back Directory | [Boiling point ]
665.2±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5.2 mg/mL (10.26 mM) | [form ]
Solid | [pka]
7.67±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1].
CDK4|2.7 nM (IC50)|CDK6|16 nM (IC50)
CDK4/6-IN-2 inhibits H358, H441, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells with IC50s of 290.9, 147.8, 260.5, 139, 36.98, 162.5, and 316.4 nM, respectively[1]. | [Uses]
CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1]. | [IC 50]
CDK4: 2.7 nM (IC50); CDK6: 16 nM (IC50) | [References]
[1]. Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1. |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
| Company Name: |
cjbscvictory
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13348960310 |
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https://www.weikeqi-biotech.com/ |
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