| Identification | Back Directory | [Name]
AB-FUBICA | [CAS]
1801338-22-6 | [Synonyms]
AB-FUBICA
eMolecules ID: 106667567
N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indole-3-carboxamide
1H-Indole-3-carboxamide, N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-[(4-fluorophenyl)methyl]- | [Molecular Formula]
C21H22FN3O2 | [MOL File]
1801338-22-6.mol | [Molecular Weight]
367.42 |
| Hazard Information | Back Directory | [Description]
AB-FUBICA (Item No. 18758) is an analytical reference material that is structurally categorized as a synthetic cannabinoid (CB). It is an indole-based CB with the structural groups found in AB-FUBINACA . The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications. | [Uses]
AB-FUBICA (Compound 13) is a CB1 and CB2 receptor agonist that activates G-protein coupled inwardly rectifying potassium channels (GIRK) by binding to CB1 and CB2 receptors, displaying notable cannabinoid-like activity. AB-FUBICA has EC50 values of 21 nM for CB1 and 15 nM for CB2. AB-FUBICA may be suitable for studying pain management, neurodegenerative diseases, and inflammation-related mechanisms[1]. | [IC 50]
CB1: 21 nM (EC50); CB2: 15 nM (EC50) | [References]
[1] Banister SD, et al. Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. ACS Chem Neurosci. 2015 Sep 16;6(9):1546-59. DOI:10.1021/acschemneuro.5b00112 |
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