| Identification | Back Directory | [Name]
3-{[4-(4-AMIDINOPHENYL)THIAZOL-2-YL][1-(CARBOXYMETHYL)-4-PIPERIDYL]AMINO}PROPIONIC ACID | [CAS]
180144-61-0 | [Synonyms]
SR121566A
3-{[4-(4-AMIDINOPHENYL)THIAZOL-2-YL][1-(CARBOXYMETHYL)-4-PIPERIDYL]AMINO}PROPIONIC ACID
1-Piperidineacetic acid, 4-[[4-[4-(aminoiminomethyl)phenyl]-2-thiazolyl](2-carboxyethyl)amino]- | [Molecular Formula]
C20H25N5O4S | [MDL Number]
MFCD00950104 | [MOL File]
180144-61-0.mol | [Molecular Weight]
431.51 |
| Chemical Properties | Back Directory | [Boiling point ]
686.0±65.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
2.47±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively. | [in vivo]
SR121566A leads to dose-dependent increases in TTO, a statistically significant increase being observed at the doses of 0.3 mg/kg (473%) and 30 mg/kg (771%), respectively[2]. | [storage]
Store at -20°C | [References]
[1] Herault JP, et al. Effect of SR121566A, a potent GP IIb-IIIa antagonist on platelet-mediated thrombin generation in vitro and in vivo. Thromb Haemost. 1998 Feb;79(2):383-8. PMID:9493595
[2] Lorrain J, et al. Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel. J Pharmacol Exp Ther. 2004 Apr;309(1):235-40. DOI:10.1124/jpet.103.059873 |
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