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1801873-49-3

1801873-49-3 Structure

1801873-49-3 Structure
IdentificationBack Directory
[Name]

OICR-0547
[CAS]

1801873-49-3
[Synonyms]

OICR-0547
3-Pyridinecarboxamide, 1,6-dihydro-N-[4-(4-morpholinyl)-3'-(4-morpholinylmethyl)[1,1'-biphenyl]-3-yl]-6-oxo-4-(trifluoromethyl)-
[Molecular Formula]

C28H29F3N4O4
[MDL Number]

MFCD30533416
[MOL File]

1801873-49-3.mol
[Molecular Weight]

542.55
Chemical PropertiesBack Directory
[Boiling point ]

701.9±60.0 °C(Predicted)
[density ]

1.358±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 100 mg/mL (184.31 mM)
[form ]

Solid
[pka]

8.84±0.10(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

OICR 0547, is a derivative of OICR-9429 (O249500), which is a chemical probe which inhibits the interaction of WDR5 (WD-repeat Protein 5) with peptide regions of MLL and Histone 3 with high selectivity. WDR5 is a part of the mixed-lineage leukemia (MLL) transferase complex that targets histone 3.
[Definition]

ChEBI: OICR-0547 is an aromatic amide.
[in vivo]

OICR-0547 (i.v, i.p.; 3, 30 mg/kg) is a suitable negative control in NOD-SCID Mice[2].

Animal Model:NOD-SCID Mice (female)[2]
Dosage:3, 30 mg/kg
Administration:IV, IP
Result:Served as a suitable negative control for biological experiments.
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1801787-56-3

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