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1802078-31-4

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1802078-31-4 Structure

1802078-31-4 Structure
IdentificationBack Directory
[Name]

Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) ammonium acetate salt
[CAS]

1802078-31-4
[Synonyms]

Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp)
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) ammonium acetate salt
Mca-(Asn???,Leu??1)-Amyloid β/A4 Protein Precursor??? (667-675)-Lys(Dnp) ammonium acetate salt
Mca-(Asn???,Leu???)-Amyloid β/A4 Protein Precursor??? (667-675)-Lys(Dnp) ammonium acetate salt
L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-
[Molecular Formula]

C68H88N14O27
[MDL Number]

MFCD31692286
[MOL File]

1802078-31-4.mol
[Molecular Weight]

1533.52
Chemical PropertiesBack Directory
[Boiling point ]

1881.2±65.0 °C(Predicted)
[density ]

1.404±0.06 g/cm3(Predicted)
[pka]

3.37±0.10(Predicted)
[Sequence]

{Mca}-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-{Lys(Dnp)}
Hazard InformationBack Directory
[Uses]

Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
[References]

[1] Vila-Real H, et al. Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. J Med Chem. 2015 Jul 23;58(14):5408-18. DOI:10.1021/acs.jmedchem.5b00658
[2] Yen YC, et al. Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors. Biochemistry. 2019 Nov 5;58(44):4424-4435. DOI:10.1021/acs.biochem.9b00714
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