| Identification | Back Directory | [Name]
Dolutegravir Impurity C | [CAS]
1802141-49-6 | [Synonyms]
Dolutegravir Impurity 20
Dolutegravir Impurity 23
(4R,12aS)-N-(2,4-difluorobenzyl)-7-ethoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1,2:
(4R,12aS)-N-(2,4-difluorobenzyl)-7-ethoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | [Molecular Formula]
C22H23F2N3O5 | [MOL File]
1802141-49-6.mol | [Molecular Weight]
447.43 |
| Hazard Information | Back Directory | [Uses]
O-Ethyl Dolutegravir is an impurity of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. |
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